Modern Aspects of Radon-Induced Lung Cancer: From Environmental Exposure to Cellular Effects. Monograph
Об издании
Radon, a naturally occurring radioactive noble gas generated from uranium decay, represents the principal source of natural ionizing radiation to the human population and is recognized as the second leading cause of lung cancer worldwide. This book presents a comprehensive analysis of radon exposure as an environmental and public health challenge, integrating global epidemiological data with a focused examination of radon-prone regions, particularly the Republic of Kazakhstan. Environmental determinants of radon accumulation in air and water, patterns of residential and occupational exposure, and international regulatory frameworks are critically evaluated to contextualize the scale and heterogeneity of radon-associated risk. Particular emphasis is placed on the molecular and cellular mechanisms underlying radon-induced lung carcinogenesis. Alpha-particle irradiation is examined in relation to DNA double-strand breaks, oxidative stress, chromosomal instability, and epigenetic alterations. The regulatory role of microRNAs, including exosomal microRNA signaling, is explored as a key mediator of radiation-induced gene expression changes. In parallel, mitochondrial dysfunction, the release of cell-free mitochondrial DNA, and the activation of inflammatory pathways are analyzed as central components of radon-driven tumor initiation and progression. The volume further addresses emerging diagnostic strategies, highlighting the translational potential of liquid biopsy technologies and multi-omic biomarker panels for early detection and risk stratification of radon-induced lung cancer. By bridging environmental exposure assessment with molecular oncology, this work provides a unified framework for understanding radon-associated carcinogenesis and supports the development of precision prevention and monitoring strategies in high-risk populations.
Библиографическая запись
Modern Aspects of Radon-Induced Lung Cancer: From Environmental Exposure to Cellular Effects : monograph / R. Bersimbaev [и др.].. — Алматы, Москва : EDP Hub (Идипи Хаб), Ай Пи Ар Медиа, 2026. — 176 c. — ISBN 978-5-4497-5334-2. — Текст : электронный // Цифровой образовательный ресурс IPR SMART : [сайт]. — URL: https://www.iprbookshop.ru/159850.html (дата обращения: 28.03.2026). — Режим доступа: для авторизир. пользователей
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Батян А.Н., Бученков И.Э., Власова Н.Г., Герасимович Н.В., Кравченко В.А., Мельнов С.Б., Пухтеева И.В.
(Адукацыя і выхаванне)
Пешехонова Е.С., Курбакова Ю.В., Киселева М.А., Зиновьева И.Н., Попова А.В., Силина О.А., Соколова М.А., Никулина Е.А.
(Московский педагогический государственный университет)
Никрошкина С.В., Скворцова Е.Б.
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Суюнчалиева О.Т.
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Данилина Е.И., Чеботарева А.А., Маликова Я.И., Чеботарев В.Е., Горелов Д.В.
(Дашков и К)
Мелёхина Е.А.
(Новосибирский государственный технический университет)
Никрошкина С.В.
(Новосибирский государственный технический университет)
Буряковская В.А., Бочарникова Н.В.
(Волгоградский государственный социально-педагогический университет, «Перемена»)